Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood
CONCLUSIONS: This study demonstrated that ADHD diagnosed later in life shows much stronger genetic overlap with internalizing disorders and related traits. This may indicate the potential clinical relevance of distinguishing these subgroups or increased misdiagnosis for those diagnosed later in life. Top transcriptome-wide SEM results implicated genes related to neuronal function and clinical characteristics (e.g., sleep).PMID:38633226 | PMC:PMC11021367 | DOI:10.1016/j.bpsgos.2024.100307 (Source: Biol Sci Space)
Source: Biol Sci Space - April 18, 2024 Category: Science Authors: Sophie Breunig Jeremy M Lawrence Isabelle F Foote Hannah J Gebhardt Erik G Willcutt Andrew D Grotzinger Source Type: research
Comparison of Opioid Use Disorder Patients with and without Problematic Internet Use in Terms of Impulsivity and Attention Deficit Hyperactivity Disorder
This study seeks to investigate ADHD symptoms and impulsivity among individuals diagnosed with Opioid Use Disorder (OUD) who also exhibit symptoms of Problematic Internet Use (PIU).METHODS: The study involved the participation of 360 Opioid Use Disorder (OUD) patients enrolled at an Alcohol and Drug Addiction Treatment Center (ADATC) during the period from October to December 2022. Various assessment tools were administered, including Young's Internet Addiction Scale (YIAS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Barratt Impulsiveness Scale (BIS), and Adult ADHD Self-Report Scale (ASRS). Problematic...
Source: Revista Brasileira de Psiquiatria - April 18, 2024 Category: Psychiatry Authors: Ne şe Burcu Bal Bahar Ye şil Örnek Source Type: research
Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood
CONCLUSIONS: This study demonstrated that ADHD diagnosed later in life shows much stronger genetic overlap with internalizing disorders and related traits. This may indicate the potential clinical relevance of distinguishing these subgroups or increased misdiagnosis for those diagnosed later in life. Top transcriptome-wide SEM results implicated genes related to neuronal function and clinical characteristics (e.g., sleep).PMID:38633226 | PMC:PMC11021367 | DOI:10.1016/j.bpsgos.2024.100307 (Source: Biol Sci Space)
Source: Biol Sci Space - April 18, 2024 Category: Science Authors: Sophie Breunig Jeremy M Lawrence Isabelle F Foote Hannah J Gebhardt Erik G Willcutt Andrew D Grotzinger Source Type: research
Comparison of Opioid Use Disorder Patients with and without Problematic Internet Use in Terms of Impulsivity and Attention Deficit Hyperactivity Disorder
This study seeks to investigate ADHD symptoms and impulsivity among individuals diagnosed with Opioid Use Disorder (OUD) who also exhibit symptoms of Problematic Internet Use (PIU).METHODS: The study involved the participation of 360 Opioid Use Disorder (OUD) patients enrolled at an Alcohol and Drug Addiction Treatment Center (ADATC) during the period from October to December 2022. Various assessment tools were administered, including Young's Internet Addiction Scale (YIAS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Barratt Impulsiveness Scale (BIS), and Adult ADHD Self-Report Scale (ASRS). Problematic...
Source: Revista Brasileira de Psiquiatria - April 18, 2024 Category: Psychiatry Authors: Ne şe Burcu Bal Bahar Ye şil Örnek Source Type: research
Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood
CONCLUSIONS: This study demonstrated that ADHD diagnosed later in life shows much stronger genetic overlap with internalizing disorders and related traits. This may indicate the potential clinical relevance of distinguishing these subgroups or increased misdiagnosis for those diagnosed later in life. Top transcriptome-wide SEM results implicated genes related to neuronal function and clinical characteristics (e.g., sleep).PMID:38633226 | PMC:PMC11021367 | DOI:10.1016/j.bpsgos.2024.100307 (Source: Biol Sci Space)
Source: Biol Sci Space - April 18, 2024 Category: Science Authors: Sophie Breunig Jeremy M Lawrence Isabelle F Foote Hannah J Gebhardt Erik G Willcutt Andrew D Grotzinger Source Type: research
Paraphilic fantasies and behavior in attention deficit/hyperactivity disorder and their association with hypersexuality
International Journal of Impotence Research, Published online: 18 April 2024; doi:10.1038/s41443-024-00891-wParaphilic fantasies and behavior in attention deficit/hyperactivity disorder and their association with hypersexuality (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - April 18, 2024 Category: Urology & Nephrology Authors: Daniel Turner Priscilla Greg ório Hertz Laura Biedermann Steffen Barra Wolfgang Retz Source Type: research
Exploring an objective measure of overactivity in children with rare genetic syndromes
This study is the first to examine the sensitivity of actigraphy to overactivity across rare genetic syndromes associated with intellectual disability, through comparisons with typically-developing peers and questionnaire overactivity estimates.MethodsA secondary analysis of actigraphy data and overactivity estimates from The Activity Questionnaire (TAQ) was conducted for children aged 4-15 years with Smith-Magenis syndrome (N=20), Angelman syndrome (N=26), tuberous sclerosis complex (N=16), and typically-developing children (N=61). Actigraphy data were summarized using the M10 non-parametric circadian rhythm variable, and...
Source: Journal of Neurodevelopmental Disorders - April 18, 2024 Category: Neurology Source Type: research
Exploring inheritance, and clinical penetrance of distal Xq28 duplication syndrome: insights from 47 new unpublished cases
ConclusionOur study provides key insights into distal Xq28 duplication. Most prenatal tests showed no major fetal ultrasound issues. Maternal inheritance was common, with unaffected mothers. In the postnatal group, a balanced gender distribution was observed. Among male family members, two fathers had ADHD, one was healthy, and one brother had mild symptoms, indicating partial penetrance in males. (Source: Journal of Human Genetics)
Source: Journal of Human Genetics - April 18, 2024 Category: Genetics & Stem Cells Source Type: research
A critical review of the dextroamphetamine transdermal system for the treatment of ADHD in adults and pediatric patients
Expert Rev Neurother. 2024 May;24(5):457-464. doi: 10.1080/14737175.2024.2329306. Epub 2024 Mar 14.ABSTRACTINTRODUCTION: The dextroamphetamine transdermal system (d-ATS) is a stimulant patch recently approved by the United States (U.S.) Food and Drug Administration for the treatment of attention-deficit/hyperactivity disorder (ADHD).AREAS COVERED: The composition of the d-ATS, pharmacokinetics, and metabolism are presented along with data from dermal trials evaluating the tolerability of patch application at various skin sites. Efficacy and safety data from a laboratory classroom study in children and adolescents including...
Source: Expert Review of Neurotherapeutics - April 17, 2024 Category: Neurology Authors: Ann Childress Nicolas Vaughn Source Type: research
The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort
CONCLUSION: Despite elevated prenatal THg exposure, no association was found with children's behavioural functioning assessed from early childhood to pre-adolescence. The nutrients in fish could offset the potential neurotoxic impact of Hg. Further birth cohort studies with longitudinal data are warranted.PMID:38631469 | DOI:10.1016/j.envres.2024.118954 (Source: Environmental Research)
Source: Environmental Research - April 17, 2024 Category: Environmental Health Authors: Blanca Sarzo Ferran Ballester Raquel Soler-Blasco Jordi Sunyer Maria-Jose Lopez-Espinosa Jesus Ibarluzea Manuel Lozano Jordi Julvez Gorka Iriarte Mikel Subiza-Perez Ll úcia González-Safont Ana Fern ández-Somoano Jorge Vallejo-Ortega M ònica Guxens Uli Source Type: research
A critical review of the dextroamphetamine transdermal system for the treatment of ADHD in adults and pediatric patients
Expert Rev Neurother. 2024 May;24(5):457-464. doi: 10.1080/14737175.2024.2329306. Epub 2024 Mar 14.ABSTRACTINTRODUCTION: The dextroamphetamine transdermal system (d-ATS) is a stimulant patch recently approved by the United States (U.S.) Food and Drug Administration for the treatment of attention-deficit/hyperactivity disorder (ADHD).AREAS COVERED: The composition of the d-ATS, pharmacokinetics, and metabolism are presented along with data from dermal trials evaluating the tolerability of patch application at various skin sites. Efficacy and safety data from a laboratory classroom study in children and adolescents including...
Source: Expert Review of Neurotherapeutics - April 17, 2024 Category: Neurology Authors: Ann Childress Nicolas Vaughn Source Type: research
