An insight into multifunctional tool box: Akkermansia muciniphila provides dynamic benefits to the human gut

Akkermansia muciniphila is a mucin degrader that plays a major role in the human gut. Multiple studies have shown that the level of abundance of this organism in the human body is inversely related to diseases, such as diabetes, obesity and inflammatory bowel disease. This organism has abilities to regulate the intestinal permeability, gut barrier and inflammatory responses in various metabolic disorders by activating various transcription factors and enhance the expression of receptors (TLRs, NLRs). Pangenome of A. muciniphila provides comprehensive detail and role of encoding genes in mitigation of metabolic dysbiosis. The present review discusses and summarizes the role of A. muciniphila in diabetes mellitus type 2, obesity, nonalcoholic fatty liver disease and other metabolic disorders.
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: BACTERIOLOGY Source Type: research