Extracts of Periplaneta americana alleviate hepatic fibrosis by affecting hepatic TGF- β and NF-κB expression in rats with pig serum-induced liver fibrosis

CONCLUSIONS: We found that EPA could reduce liver inflammation, suppress liver cell degeneration and necrosis, and reduce the formation of liver fibrous tissue. Its mechanism might be associated with inhibiting the expression of TGF-β1, TIMP-1, NF-κB and α-SMA to block signal transduction pathways in the hepatic fibrosis process. Therefore, EPA, as a traditional Chinese medicine, might be potentially used to prevent and treat hepatic fibrosis in the future. However, further more experiments are necessary to verify its effectiveness and possible signaling pathways.PMID:35575220 | DOI:10.5603/FHC.a2022.0011
Source: Folia Histochemica et Cytobiologica - Category: Cytology Authors: Source Type: research