Genetics of atrial fibrillation-an update of recent findings

Mol Biol Rep. 2022 May 19. doi: 10.1007/s11033-022-07420-2. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified. The recent studies have contributed towards better understanding of AF pathogenesis.PMID:35587846 | DOI:10.1007/s11033-022-07420-2
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research