COVID-19 and Diabetic Nephropathy
Horm Metab Res DOI: 10.1055/a-1819-4822Diabetic nephropathy is the most common condition that requires a chronic renal
replacement therapy, such as hemodialysis, peritoneal dialysis, kidney
transplantation, or simultaneous kidney-pancreas transplantation. Chronic kidney
disease progression, that is the loss of nephrons, which causes the continuous
decline of the eGFR, underlies the pathogenesis of diabetic nephropathy. During
the COVID-19 pandemic, it became clear that diabetic nephropathy is amongst the
independent risk factors that predicts unfavourable outcome upon SARS-CoV2
infection. While we still lack conclusive mechanistic insights into how nephrons
are rapidly lost upon SARS-CoV2 infection and why patients with diabetic
nephropathy are more susceptible to severe outcomes upon SARS-CoV2 infection,
here, we discuss several aspects of the interface of COVID-19 with diabetic
nephropathy. We identify the shortage of reliable rodent models of diabetic
nephropathy, limited treatment options for human diabetic nephropathy and the
lack of knowledge about virus-induced signalling pathways of regulated necrosis,
such as necroptosis, as key factors that explain our failure to understand this
system. Finally, we focus on immunosuppressed patients and discuss vaccination
efficacy in these and diabetic patients. We conclude ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Maremonti, Francesca Locke, Sophie Tonnus, Wulf Beer, Kristina Brucker, Anne Gonzalez, Nadia Zamora Latk, Marcus Belavgeni, Alexia Hoppenz, Paul Hugo, Christian Linkermann, Andreas Tags: Review Source Type: research
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