Role of Exosomes and its emerging therapeutic applications in the pathophysiology of Non-Infectious disease

Biomarkers. 2022 Apr 22:1-53. doi: 10.1080/1354750X.2022.2067233. Online ahead of print.ABSTRACTExosomes are a type of small Extracellular Vesicles (EVs) and play crucial roles in cancer and other diseases. Exosomes role in various diseases has been studied as they regulate intercellular communication and are obtained from almost any part of the body. Exosomes use is complicated in diseases as they promote pathogenesis but also act as a very good therapeutic agent in most diseases. The presence of a complex molecular cargo consisting of nucleic acids (DNA, RNA, miRNA, siRNA, etc.,) makes it a very good delivery agent and acts as a biomarker for many cancers, cardiovascular and neurodegenerative diseases. They can be used to selectively target cells and activate immune cell responses depending on the source obtained. Exosomes based immunotherapy is an area of gaining importance due to the proteins present in them and their specificity to the targeted cells. The role of exosomes in the diagnosis and treatment of non-infectious diseases is discussed in detail in this article.PMID:35451890 | DOI:10.1080/1354750X.2022.2067233
Source: Biomarkers - Category: Research Authors: Source Type: research