Metabolic therapy for managing heart failure with preserved ejection fraction

The global increase in average life expectancy and the pandemics of obesity, diabetes, and hypertension, have pushed the prevalence of heart failure with preserved fraction (HFpEF) to the edge of socioeconomic sustainability [1]. Sedentary lifestyle and obesogenic diets are major drivers of metabolic disorders and multimorbidities, which exacerbate one another and promote age-related diastolic dysfunction, leading to HFpEF through multiple, albeit poorly characterized, signaling pathways and mechanisms [2].
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research