Caveolins: Expression of Regulating Systemic Physiological Functions in Various Predicaments
Drug Res (Stuttg) DOI: 10.1055/a-1785-4133Caveolins are membrane proteins which contains caveolae. They are present in the
plasma membrane. Many researchers found that caveolae have been associated with
expression of the caveolins in major physiological networks of mammalian cells.
Subtypes of caveolin including caveolin-1 and caveolin-2 have been found in
micro arteries of rat brain, while caveolin-3 has been found in astrocytes.
Caveolin-1 and caveolae play important roles in Alzheimer’s disease,
cancer, ischemic preconditioning-mediated cardio-protection, postmenopausal
alterations in women, and age-related neurodegeneration. Caveolin-1 may modify
fatty acid transmembrane flux in adipocytes. The discovery of a link between
ischemia preconditioning, cardio-protection, and endothelial nitric oxide
synthase has supported cardiovascular research tremendously. Therefore,
caveolins are effective in regulation of cellular, cardiovascular, brain, and
immune processes. They ascertain new signalling pathways and link the
functionalities of these pathways. This review paper focuses on contribution of
caveolins in various conditions, caveolin expression at the molecular level and
their physiological effects in many organ systems. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Upadhyay, Prabhat Kumar Vishwakarma, Vishal Kumar Srivastav, Ritesh Kumar Tags: Review Source Type: research
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