Complementary medicines and dietary Supplement in eradication of Helicobacter pylori; A comprehensive review

Helicobacter pylori (H. pylori) is one of the most common causes of gastrointestinal disorders in humans, and approximately about 50% of the world's population are infected with this bacterium. Recently, the standard triple or quadruple therapies have become the most effective protocol for the eradication of H. pylori infections. However, the emergence of antibiotic-resistant H. pylori isolates has become a global problem. There are evidence regarding the impact of different complementary or dietary supplements on H. pylori eradication. This review article intended to search electronic bibliographic databases for any clinical studies that evaluated the use of any herbal or dietary supplements to eradicate H. pylori up to June 2021. A total of 48 clinical trials met our criteria and were included in the present review. Although some herbal medicines have shown their efficacy and safety in the eradication of H. pylori in different clinical trials, further double-blind, randomized, placebo-controlled clinical trials with a large sample size are needed to extend our knowledge.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research