Development of biocompatible nanoparticles of tizanidine hydrochloride in orodispersible films: In vitro characterization, ex vivo permeation and cytotoxic study on carcinoma cells

CONCLUSION: A study of cytotoxic effect on the MCF-7 breast cancer cells and A549 lung carcinoma cells revealed that tizanidine hydrochloride nanoparticles at 2.3 mg/film exhibited an IC50 value of 65.1 % cytotoxicity on MCF-7, approximately 100% on HOP92, and 83.5 % on A549 lung carcinoma cells, thus paving the way for a new paradigm of research for cytotoxic study on MCF-7, HOP92 and A549 cell lines using the subject drug model prepared as oral films or biodegradable nanoparticles in oral films for site-specific targeting.PMID:35319369 | DOI:10.2174/1567201819666220321111338
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research