Anti-HIV Drugs Cause Mitochondrial Dysfunction in Monocyte-Derived Macrophages

We report that Triumeq skewed alternative MDMs toward an inflammatory nonsenescent phenotype. Both Atripla and Triumeq caused mitochondrial dysfunction, specifically efavirenz and abacavir. Additionally, transcriptome sequencing (RNA-seq) demonstrated that both Atripla and Triumeq caused differential regulation of genes involved in immune regulation and cell cycle and DNA repair. Collectively, our data demonstrate that cART, independent of HIV, alters the MDM phenotype. This suggests that cART may contribute to cell dysregulation in PLWH that subsequently results in increased susceptibility to comorbidities.PMID:35293780 | DOI:10.1128/aac.01941-21

Source: Antimicrobial Agents and Chemotherapy - March 16, 2022 Category: Microbiology Authors: Jennillee Wallace Hemil Gonzalez Reshma Rajan Srinivas D Narasipura Amber K Virdi Arnold Z Olali Ankur Naqib Zarema Arbieva Mark Maienschein-Cline Lena Al-Harthi Source Type: research