A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia [Cell Biology]
Acute myeloid leukemias (AMLs) with the NUP98-NSD1 or mixed lineage leukemia (MLL) rearrangement (MLL-r) share transcriptomic profiles associated with stemness-related gene signatures and display poor prognosis. The molecular underpinnings of AML aggressiveness and stemness remain far from clear. Studies with EZH2 enzymatic inhibitors show that polycomb repressive complex 2 (PRC2)...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Zhihong Ren, Arum Kim, Yu-Ting Huang, Wen-Chieh Pi, Weida Gong, Xufen Yu, Jun Qi, Jian Jin, Ling Cai, Robert G. Roeder, Wei-Yi Chen, Gang Greg Wang Tags: Cell Biology Biological Sciences Source Type: research
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