A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia [Cell Biology]

Acute myeloid leukemias (AMLs) with the NUP98-NSD1 or mixed lineage leukemia (MLL) rearrangement (MLL-r) share transcriptomic profiles associated with stemness-related gene signatures and display poor prognosis. The molecular underpinnings of AML aggressiveness and stemness remain far from clear. Studies with EZH2 enzymatic inhibitors show that polycomb repressive complex 2 (PRC2)...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Cell Biology Biological Sciences Source Type: research