Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles
Social isolation influences depression- and anxiety-related disorders and altered cardiac function. Oxytocin may mediate these conditions through interactions with social behavior, emotion, and cardiovascular function, via central and/or peripheral mechanisms. The present study investigated the influence of oxytocin antagonism using L-368,899, a selective oxytocin receptor antagonist that crosses the blood-brain barrier, on depression- and anxiety-related behaviors and heart rate in prairie voles.
Source: Autonomic Neuroscience: Basic and Clinical - Category: Neuroscience Authors: W. Tang Watanasriyakul, Melissa-Ann L. Scotti, C. Sue Carter, Neal McNeal, William Colburn, Joshua Wardwell, Angela J. Grippo Source Type: research
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