Toxicity of Hydrogen Sulfide on Rat Brain Neurons
This study investigated the mechanisms of cytotoxicity induced by
H2S in brain neurons. thioacetamide has been used to produce
H2S in water solutions. The results of the study showed that
thioacetamide at concentrations of 116, 232 and
464 µg/ml was able to increase the level of reactive
oxygen species (ROS), collapse in mitochondrial membrane potential (MMP), damage
to the lysosomal membrane, increase in the level of oxidized glutathione (GSSG)
and decrease in the level of reduced glutathione (GSH) in brain neurons. The
results of the study suggested that H2S causes damage to mitochondria
and lysosomes in brain neurons that could be associated with neurodegenerative
diseases. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Seydi, Enayatollah Irandoost, Zahra Khansari, Mahmoud Ghazi Naserzadeh, Parvaneh Tanbakosazan, Farahnaz Pourahmad, Jalal Tags: Original Article Source Type: research
More News: Brain | Drugs & Pharmacology | Mitochondria | Mitochondrial Disease | Neurology | Respiratory Medicine | Study | Toxicology