Whole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot study

Acute lymphoblastic leukemia (ALL) is the most common cancer in children and although treatment has improved, almost 50% of patients experience severe non-infectious side effects [1,2]. Hyperlipidemia is common during concomitant therapy with dexamethasone and pegylated-asparaginase (PEG-ASP) [3 –5] with triglyceride (TG) levels up to 200 times the upper normal limit [6]. Plasma TG can be reduced by supplementation with n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) [7–9].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research