A Nutrigenetic Update on CETP Gene –Diet Interactions on Lipid-Related Outcomes

The objective of this review was to identify and discuss nutrigenetic studies assessing the interactions betweenCETP SNPs and dietary factors on blood lipids.Recent FindingsRelevant articles were obtained through a literature search of PubMed and Google Scholar through to July 2021. An article was included if it examined an interaction betweenCETP SNPs and dietary factors on blood lipids. From 49 eligible nutrigenetic studies, 27 studies reported significant interactions between 8CETP SNPs and 17 dietary factors on blood lipids in 18 ethnicities. The discrepancies in the study findings could be attributed to genetic heterogeneity, and differences in sample size, study design, lifestyle and measurement of dietary intake. The most extensively studied ethnicities were those of Caucasian populations and majority of the studies reported an interaction with dietary fat intake. The rs708272 (TaqIB) was the most widely studiedCETP SNP, where ‘B1’ allele was associated with higherCETP activity, resulting in lower high-density lipoprotein cholesterol and higher serum triglycerides under the influence of high dietary fat intake.SummaryOverall, the findings suggest thatCETP SNPs might alter blood lipid profiles by modifying responses to diet, but further large studies in multiple ethnic groups are warranted to identify individuals at risk of adverse lipid response to diet.
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research