Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits

ConclusionsIn this preclinical study, mesenchymal stem cells improved the outcome of rabbits with pneumonia and high-pressure mechanical ventilation by correcting immune and mitochondrial dysfunction and when combined with the antibiotic ceftaroline was synergistic in mitigating lung inflammation.Editor ’s PerspectiveWhat We Already Know about This TopicMultiple factors, including mitochondrial dysfunction, contribute to lung injury during mechanical ventilation for pneumoniaMesenchymal stem cells have been shown to have potential reparative effects that may attenuate injuryWhat This Article Tells Us That Is NewIn a preclinical study, mesenchymal stem cell administration improved the outcome of rabbits with pneumonia and high-pressure mechanical ventilation by correcting immune and mitochondrial dysfunctionWhen combined with specific antibiotic therapy, the combination was synergistic in mitigating lung inflammation

Source: Anesthesiology - January 16, 2022 Category: Anesthesiology Source Type: research