RBM20S639G mutation is a high genetic risk factor for premature death through RNA-protein condensates

In this study, we generated a RBM20 S639G mutation knock-in (KI) mouse model to validate the function of S639G mutation and examine the underlying mechanisms.

Source: Journal of Molecular and Cellular Cardiology - January 15, 2022 Category: Cytology Authors: Chunyan Wang, Yanghai Zhang, Mei Methawasin, Camila Urbano Braz, Jeffrey Gao-Hu, Betty Yang, Joshua Strom, Jochen Gohlke, Timothy Hacker, Hasan Khatib, Henk Granzier, Wei Guo Source Type: research