Impact of Clinical Sepsis Phenotypes on Mortality and Fluid Status in Critically Ill Patients

Background: Sepsis is associated with high rates of in-hospital mortality, despite being the focus of medical research and public health initiatives for several years. The primary objective of this study was to determine the influence of septic phenotypes on rates of in-hospital mortality throughout intensive care unit (ICU) admission. Patients and Methods: Retrospective, single-center cohort study. Medical ICU of an academic medical center. Medical ICU patients admitted between January 2016 and August 2019 with a “sepsis alert” were screened for admitting diagnosis of “sepsis” or “septic shock.” Patients were classified into one of four clinical sepsis phenotypes: multi-organ failure (MOF), respiratory dysfunction (RD), neurologic dysfunction (ND), or other patients (OP). Results: An analysis of 320 patients was completed. In-hospital mortality was different between groups (P 
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research