Chemoprevention by aspirin against inflammation-related colorectal cancer in mice

J Clin Biochem Nutr. 2021 Nov;69(3):265-271. doi: 10.3164/jcbn.20-189. Epub 2021 May 28.ABSTRACTInflammation is a primary risk factor for cancer. Epidemiological studies previously demonstrated that aspirin decreased the incidence of cancer and specifically reduced the risk of colorectal cancer. However, the number of animal studies that have confirmed the efficacy of aspirin remains limited. Therefore, the purpose of the present study was to investigate the mechanisms by which aspirin prevents colorectal cancer in mice. ICR mice were treated with azoxymethane and the ulcerative colitis inducer, dextran sodium sulfate, to induce colorectal tumors. Aspirin was orally administered three times per week for 12 weeks. Aspirin significantly reduced the number and size of colorectal tumors. Aspirin also significantly decreased tumor necrosis factor alpha and reactive oxygen species (ROS) levels in the plasma. Immunohistochemical analyses and western blots showed that cyclooxygenase 2 (COX2), inducible nitric oxide synthase (iNOS), and the active form of Yes-associated protein 1 (YAP1), and cytosolic high mobility group box 1 (HMGB1) were strongly expressed at colorectal tumor sites and clearly suppressed by aspirin. An indicator of inflammation-related DNA damage, 8-nitroguanine, also accumulated in the colorectal tissues and was suppressed by aspirin. The present results suggest that the ingestion of aspirin suppressed carcinogenesis caused by inflammation through decreases in COX2...
Source: Clinical Biochemistry - Category: Biochemistry Authors: Source Type: research

Related Links:

Ann Surg Oncol. 2022 Jan 11. doi: 10.1245/s10434-021-11307-0. Online ahead of print.NO ABSTRACTPMID:35015182 | DOI:10.1245/s10434-021-11307-0
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
In this study, we show that the mechanism responsible for the protective effect of 5-ASA is associated with the modulation of non-coding microRNA molecule (miRNA) expression. Stimulation of human intestinal epithelial cells (Caco-2) with 1000 μM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. The 5-ASA-induced inhibitions of these miRNAs were associated with significant inductions of their target genes such as vitamin D receptor (VDR), suppressor of cytokine...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
We present these studies with a focus on two chemokines: CXCL8 (IL-8) and CCL2 (chemoattractant protein 1 or MCP-1). Future research will further elucidate the precise potential of curcumin on chemokines in the adjustment of cardiovascular system activity or curcumin chemokine-based therapies.PMID:34981477 | DOI:10.1007/978-3-030-73234-9_11
Source: Advances in Experimental Medicine and Biology - Category: Research Authors: Source Type: research
Thymosin β4 (Tβ4) is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation. Moreover, Tβ4 is effectively utilized for several indications in animal experiments or clinical trials, such as myocardial infarction and myocardial ischemia-reperfusion injury, xerophthalmia, liver and renal fibrosis, ulcerative colitis and colon cancer, and skin trauma. Recent studies have reported the potential application of Tβ4 and its underlying me...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Ulcerative colitis (UC) is a chronic inflammatory disease of unknown cause characterized by mucosal inflammation of colon and rectum. Goal of treatment is to reduce mucosal inflammation and to prevent disability, colectomy and colorectal cancer. Aminosalicylates, corticosteroids and thiopurines alone or in combination are established as initial therapies. In recent years various biologicals extended the therapeutic armamentarium in particular for patients refractory or intolerant to conventional therapies or having more severe disease.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Issue Highlights Source Type: research
CONCLUSION: IBD is not uncommon in African patients, with UC being more frequent than CD. Postoperative mortality and potential for malignant transformation are higher for UC.PMID:34889541
Source: South African Journal of Surgery - Category: Surgery Authors: Source Type: research
More News: Aspirin | Biochemistry | Cancer | Cancer & Oncology | Colorectal Cancer | Epidemiology | Inflammatory Bowel Disease | Sodium | Study | Ulcerative Colitis