The bronchiectasis 'bacteriophagome

Introduction: The clinical relevance of bacteriophages in bronchiectasis remains unknown.Aim: To evaluate the bacteriophagome in bronchiectasis and assess correlation with antimicrobial resistance (AMR) and clinical status.Methods: We performed the largest metagenomic study in bronchiectasis to date (n=251) recruiting patients from four countries: Singapore (n=94), Malaysia (Kuala Lumpur) (n=38), Scotland (Dundee) (n=94) and Italy (Milan) (n=25). Patients were ‘matched’ by age, gender, and exacerbation status to allow for geographic comparisons. All specimens were subjected to whole-genome shotgun metagenomic sequencing and bioinformatic analysis to assess bacteriophages and AMR genes.Results: In supervised analysis, geographic differences in bacteriophages were evident, with Myoviridae increased in Europeans (Dundee/Milan) and Phycodnaviridae overrepresented in Asians (Singapore/Malaysia) (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections and bronchiectasis Source Type: research

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Semin Respir Crit Care Med. 2022 Jan 21. doi: 10.1055/s-0041-1740109. Online ahead of print.ABSTRACTPseudomonas aeruginosa (PA), a non-lactose-fermenting gram-negative bacillus, is a common cause of nosocomial infections in critically ill or debilitated patients, particularly ventilator-associated pneumonia (VAP), and infections of urinary tract, intra-abdominal, wounds, skin/soft tissue, and bloodstream. PA rarely affects healthy individuals, but may cause serious infections in patients with chronic structural lung disease, comorbidities, advanced age, impaired immune defenses, or with medical devices (e.g., urinary or in...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
This study will use a multicentre, open-label non-inferiority trial design comparing cefiderocol and standard of care antibiotics. Eligible participants will be adult inpatients who are diagnosed with a bloodstream infection with a Gram-negative organism on the basis of a positive blood culture result where the acquisition meets the definition for healthcare-associated or hospital-acquired. It will compare cefiderocol with the current standard of care (SOC) antibiotic regimen according to the patient ’s treating clinician. Eligible participants will be randomised 1:1 to cefiderocol or SOC and receive 5–14&thins...
Source: Trials - Category: Research Source Type: clinical trials
Purpose of review Gram-negative bloodstream infections (GNBSI) are common and carry considerable mortality. Treatment is complicated by increasing antimicrobial resistance, posing a challenge for timely appropriate antibiotics and limiting the choices of effective definitive therapy. The present review aims to summarize recent studies addressing the management of GNBSI. Recent findings New rapid diagnostic tests (RDT) for pathogen identification and antibiotic susceptibility are associated with improved antimicrobial stewardship and reduced length of stay. No mortality benefit or patient-related outcomes are rep...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: ANTIMICROBIAL AGENTS: BACTERIAL/FUNGAL: Edited by Monica A. Slavin Source Type: research
CONCLUSION: The identification of risk factors for antimicrobial resistance and analysis of antimicrobial susceptibility might be important for concordant empirical antimicrobial therapy in patients with P. aeruginosa bacteremia.PMID:34751008 | DOI:10.3346/jkms.2021.36.e273
Source: Journal of Korean Medical Science - Category: Biomedical Science Authors: Source Type: research
CONCLUSIONS: Plasmid-mediated spread of AmpC is present in clinically relevant Enterobacteriaceae species in Bahrain. Rational antimicrobial therapy against these multidrug-resistant organisms and continued surveillance of antimicrobial resistance mechanisms among the clinical isolates are recommended for optimal patient care.
Source: Annals of Thoracic Medicine - Category: Respiratory Medicine Authors: Source Type: research
We present a patient with the typical manifestations of CBP. The patient underwent multiple courses of antibiotic treatment without any long-term resolution of his symptoms. Testing of prostatic secretion and semen samples revealed pathogenic bacteria in each case, which collectively included members of the Staphylococcal species such as Methicillin resistant Staphylococcus aureus (MRSA) and Staphylococcus haemolyticus, Enterococcus faecalis, and Streptococcus mitis, among others.Methods and Outcome: Bacteriophage preparations from the Eliava Institute were used to treat the patient after establishing phage sensitivity to ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS AND CLINICAL IMPORTANCE: Bacteriophage therapy is one of the most promising approaches to tackling the looming antimicrobial resistance crisis, yet substantial regulatory challenges will need to be overcome before it enters widespread use. Phage therapy also may, in the future, improve the management of challenging bacterial infections that are not necessarily multidrug-resistant.PMID:33870572 | DOI:10.1111/vde.12958
Source: Veterinary Dermatology - Category: Veterinary Research Authors: Source Type: research
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