Long-term radiation therapy-related risk of second primary malignancies in patients with lung cancer

This study aims to investigate the long-term risk of a SPM attributable to the radiation therapy in patients with the initial lung cancer.METHODS: Patients initially diagnosed with lung cancer between January 1975 and November 2011 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. SPM was defined as the occurrence of a second cancer at least five years after the diagnosis of the initial lung cancer. Age- and propensity score matching (PSM)-adjusted competing risk analyses were performed to compare the risk of SPM.RESULTS: Of 47,911 patients, 9,162 (19.1%) underwent radiotherapy for the initial lung cancer. The PSM-adjusted competing risk analyses showed that radiation therapy was associated with a lower overall risk of SPM (HR: 0.89, 95% CI: 0.84-0.94, P
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Authors: Source Type: research

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This study aims to investigate the long-term risk of a SPM attributable to the radiation therapy in patients with the initial lung cancer.METHODS: Patients initially diagnosed with lung cancer between January 1975 and November 2011 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. SPM was defined as the occurrence of a second cancer at least five years after the diagnosis of the initial lung cancer. Age- and propensity score matching (PSM)-adjusted competing risk analyses were performed to compare the risk of SPM.RESULTS: Of 47,911 patients, 9,162 (19.1%) underwent radiotherapy for the i...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Authors: Source Type: research
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