Behavioral, hormonal, and neural alterations induced by social contagion for pain model in mice

Neuropharmacology. 2021 Nov 10:108878. doi: 10.1016/j.neuropharm.2021.108878. Online ahead of print.ABSTRACTNeurobiology of social contagion/empathy aims to collaborate with the development of treatments for human disorders characterized by the absence of this response - autism spectrum disorder, schizophrenia, and antisocial personality disorder. Previous studies using sustained aversive stimuli (e.g., neuropathic pain or stress) to induce social contagion behaviors in rodents have demonstrated that these conditions may increase hypernociception, anxiogenic-like effects, and defensive behaviors in cagemates. To amplify the knowledge about behavioral, hormonal, and neural alterations induced by cohabitation with a pair in neuropathic pain, we investigated the effects of this protocol on (i) pain (writhing, formalin, hot plate tests) and depression (sucrose splash test) responses, (ii) the serum levels of corticosterone, testosterone, and oxytocin, (iii) noradrenalin, dopamine and its metabolite (DOPAC and HVA) levels in the amygdaloid complex and insular cortex, (iv) neuronal activation pattern (FosB labeling) in the ventral tegmental area (VTA), paraventricular nucleus of the hypothalamus (PVN) and supraoptic nucleus (SO). One day after weaning, male Swiss mice were housed in pairs for 14 days. Then, they were divided into two groups: sciatic nerve constricted cagemate [CNC; i.e., one animal of each pair was subjected to sciatic nerve constriction (NC)], and cagemate sham (C...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research

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Hi everyone, I am turning 34 soon (female) and I am two quarters from completing my masters in computer science with a 3.85 gpa. I have a job waiting in July thank goodness. In undergrad I had some mental health issues mainly depression that messed with my grades. So I needed up with a 3.32 cGPA and probably a 3.0 sGPA. I chose computer science because it is intellectually stimulating and as I developed psychosis from the long term depression (which is very well managed now) I didn’t... Read more
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Ian Alexander Jr., the only son of actress Regina King, has died by suicide. King issued a statement to People magazine on her loss. “Our family is devastated at the deepest level by the loss of Ia… #reginaking #ianalexanderjr
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, the studies presented in the current review demonstrate that CBD has the potential to limit delta-9-THC-induced cognitive impairment and improve cognitive function in various pathological conditions. Human studies suggest that CBD may have a protective role in delta-9-THC-induced cognitive impairments; however, there is limited human evidence for CBD treatment effects in pathological states (e.g. schizophrenia). In short, they found that CBD may help alleviate the negative impact of a person with schizophrenia from taking cannabis, both in the psychotic and cognitive symptoms associated with schizophrenia. T...
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Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Psychiatry Source Type: blogs
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Source: Science - The Huffington Post - Category: Science Source Type: news
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Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
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