Cutaneous iontophoresis of vasoactive medications in patients with scleroderma ‐associated pulmonary arterial hypertension

ConclusionsPatients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests, presumably due to a peripheral reduction in prostacyclin receptor expression and nitric oxide bioavailability.

Source: Microcirculation - November 17, 2021 Category: Research Authors: Sami Al Abdi, Allaa Almoushref, Tawfeq Naal, Celia A. Melillo, Kulwant S. Aulak, Mostafa K. Ahmed, Soumya Chatterjee, Kristin B. Highland, Raed A. Dweik, Adriano R. Tonelli Tags: ORIGINAL ARTICLE Source Type: research