Characterization of maturation of neuronal voltage-gated sodium channels SCN1A and SCN8A in rat myocardium
Conclusions
Heart- and brain-type sodium channels are differentially expressed during ontogenesis. The high expression level of SCN1A in the perinatal period and early infancy indicates its importance in preserving a regular cardiac rhythm in this early phase of life. Altered regulation of sodium channels might result in severe cardiac rhythm disturbances.
Source: Molecular and Cellular Pediatrics - Category: Cytology Source Type: research
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