Molecules, Vol. 26, Pages 6752: Attenuative Effects of Fluoxetine and Triticum aestivum against Aluminum-Induced Alzheimer ’s Disease in Rats: The Possible Consequences on Hepatotoxicity and Nephrotoxicity

Conclusions: AlCl3 elevated liver and kidney enzymes, over-production of oxidative stress, and inflammatory markers. Besides, accumulation of tau protein and Aβ, the elevation of ACHE and GSK-3β, down-regulation of BDNF, and β–catenin expression in the brain. Histopathological examinations of the liver, kidney, and brain confirmed this toxicity, while treating AD groups with fluoxetine, wheatgrass, or a combination alleviates toxic insults. Conclusion: Fluoxetine and wheatgrass combination demonstrated a more significant neuroprotective impact in treating AD than fluoxetine alone and has protective effects on liver and kidney tissues.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research