Genes, Vol. 12, Pages 1665: Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells

Genes, Vol. 12, Pages 1665: Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells Genes doi: 10.3390/genes12111665 Authors: Christophe E. Redon Zoe Schmal Gargi Tewary Adèle Mangelinck Régis Courbeyrette Jean-Yves Thuret Mirit I. Aladjem William M. Bonner Claudia E. Rübe Carl Mann H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research