Genes, Vol. 12, Pages 1665: Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
Genes, Vol. 12, Pages 1665: Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
Genes doi: 10.3390/genes12111665
Authors:
Christophe E. Redon
Zoe Schmal
Gargi Tewary
Adèle Mangelinck
Régis Courbeyrette
Jean-Yves Thuret
Mirit I. Aladjem
William M. Bonner
Claudia E. Rübe
Carl Mann
H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.
Source: Genes - Category: Genetics & Stem Cells Authors: Christophe E. Redon Zoe Schmal Gargi Tewary Ad èle Mangelinck R égis Courbeyrette Jean-Yves Thuret Mirit I. Aladjem William M. Bonner Claudia E. R übe Carl Mann Tags: Article Source Type: research
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