Field evaluation of BNT162b2 COVID-19 vaccine response in healthcare workers: a 3-month follow-up

ConclusionsOur results showed that surveillance is a critical component of providing safe healthcare during COVID-19 pandemic, also after extended vaccination campaigns, thus enhancing the protection of patients and HCWs.Key messagesAll healthcare facilities should implement continuous post-vaccination surveillance programs in order to ensure patients and healthcare workers safety, and limit in-hospital transmission of SARS-CoV-2.Longer field follow-ups are indispensable to investigate immunogenicity trends and effectiveness of COVID-19 vaccines over time, and to consider booster doses, especially in high-risk population.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research

Related Links:

Turk J Med Sci. 2021 Nov 30. doi: 10.3906/sag-2110-179. Online ahead of print.ABSTRACTIn the Wuhan province of China, almost two years ago, in December 2019, the novel Coronavirus 2019 has caused a severe involvement of the lower respiratory tract leading to an acute life-threatening respiratory syndrome, coronavirus disease-19 (COVID-19). Subsequently, coronavirus 2 (SARS-CoV-2) rapidly spread to entire world causing a pandemic and affected every single person on earth either directly or indirectly with destroying all faucets of social life and economy. Since the announcement of COVID-19 as a global pandemic, we witnessed...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Authors: Source Type: research
This article examines the background to INN for vaccines and explains the applicability and value of assigning INN to novel well-defined vaccines.PMID:34844820 | DOI:10.1016/j.vaccine.2021.11.054
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Viruses, Vol. 13, Pages 2405: Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population Viruses doi: 10.3390/v13122405 Authors: Carlos A. Sariol Crisanta Serrano-Collazo Edwin J. Ortiz Petraleigh Pantoja Lorna Cruz Teresa Arana Dianne Atehortua Christina Pabon-Carrero Ana M. Espino The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show tha...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
IJERPH, Vol. 18, Pages 12636: β-Glucans Could Be Adjuvants for SARS-CoV-2 Virus Vaccines (COVID-19) International Journal of Environmental Research and Public Health doi: 10.3390/ijerph182312636 Authors: Alfredo Córdova-Martínez Alberto Caballero-García Enrique Roche David C. Noriega Waiting for an effective treatment against the SARS-CoV-2 virus (the cause of COVID-19), the current alternatives include prevention and the use of vaccines. At the moment, vaccination is the most effective strategy in the fight against pandemic. Vaccines can be administered with different natural biolog...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread worldwide. The Delta (B.1.617.2) variant was first reported in India in October 2020 and was classified as a “variant of concern (VOC)” by the WHO on 11 May, 2021. Compared to the wild-type strain, several studies have shown that the Delta variant is more transmissible and has higher viral loads in infected samples. COVID-19 patients infected with the Delta variant have a higher risk of hospitalization, intensive care unit (ICU) admission, and mortality. The Delta variant is becoming the dominant strain in many countries around the world....
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Since the emergence of the COVID-19 pandemic, Johnson &Johnson (the Company) has been closely monitoring newly emerging COVID-19 variants. In collaboration with academic groups in South Africa and around the world, the Company has been evaluating the effectiveness of its COVID-19 vaccine across variants, including now the new and rapidly spreading Omicron variant. The Company is testing blood serum from participants in completed and ongoing booster studies to look for neutralizing activity against the Omicron variant. In addition, the Company is pursuing an Omicron-specific variant vaccine and will progress it as neede...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Br J Dermatol. 2021 Nov 29. doi: 10.1111/bjd.20906. Online ahead of print.ABSTRACTPatients with autoimmune bullous diseases (AIBDs) have faced considerable challenges during the COVID-19 outbreak.1 SARS-CoV-2 vaccines became an important public health solution, but the pandemic raised awareness of vaccine hesitancy.2 We aimed to investigate the currently unknown general vaccination status among AIBD patients to better inform vaccine practices in this cohort of potentially life-threatening inflammatory disorders.PMID:34842282 | DOI:10.1111/bjd.20906
Source: The British Journal of Dermatology - Category: Dermatology Authors: Source Type: research
J Immunol Methods. 2021 Nov 26:113195. doi: 10.1016/j.jim.2021.113195. Online ahead of print.ABSTRACTCOVID-19 pandemic poses a serious threat to human health; it has completely disrupted global stability, making vaccine development an important goal to achieve. Monoclonal antibodies play an important role in subunit vaccines strategies. In this work, nine murine MAbs against the RBD of the SARS-CoV-2 spike protein were obtained by hybridoma technology. Characterization of purified antibodies demonstrated that five of them have affinities in the order of 108 L/mol. Six of the eight MAbs showed specific recognition of differ...
Source: Journal of Immunological Methods - Category: Allergy & Immunology Authors: Source Type: research
AbstractPurpose of ReviewThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into a global pandemic that affect the health of hundreds of millions worldwide. In particular, SARS-CoV-2 infection in people with chronic human immune deficiency virus (HIV) infection is of concern, due to their already immunocompromised status. Yet, whether and how the immunological changes brought about by HIV will affect the immune responses against SARS-CoV-2 acute infection and impact the effectiveness of vaccines remain unclear. We discuss the intersection of COVID-19 in HIV-infected individuals.Recent FindingsPe...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
Since its emergence in Wuhan, China, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread very rapidly around the world, resulting in a global pandemic. Though the vaccination process has started, the number of COVID-affected patients is still quite large. Hence, an analysis of hotspot mutations of the different evolving virus strains needs to be carried out. In this regard, multiple sequence alignment of 71,038 SARS-CoV-2 genomes of 98 countries over the period from January 2020 to June 2021 is performed using MAFFT followed by phylogenetic analysis in order to visualize the virus evolution. These steps...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
More News: Allergy & Immunology | Chemistry | COVID-19 | General Medicine | International Medicine & Public Health | Italy Health | Laboratory Medicine | Pandemics | SARS | Statistics | Study | Vaccines