Nobel prize in medicine awarded to US duo for work on sense of touch
David Julius and Ardem Patapoutian share 10m-kronor prize for discovery of receptors for temperature and touchTwo US researchers have won the 2021 Nobel prize in physiology or medicine for work that unlocked the secrets of the sense of touch.Prof David Julius, a physiologist at the University of California in San Francisco, and Prof Ardem Patapoutian, a neuroscientist at Scripps Research in La Jolla, California, were honoured for their discovery of receptors in the skin that sense heat, cold and touch – making them crucial for survival. The work paves the way for a range of new medical treatments for conditions such as chronic pain.Continue reading...
Chronic groin pain (CGP), defined as pain beyond two months, is a rare but potentially debilitating complication of inguinal hernia repair. CGP etiologies include neuropathic, mesh-related, hernia-related, musculoskeletal, and urologic. Treatment options depend on the nature of the pain. Preoperative history, physical exam and imaging studies can help elucidate the cause, while surgical exploration and interventions are sometimes required. The purpose of this study was to evaluate the outcomes following CGP surgical treatment.
Conditions: Pain, Postoperative; Pain, Acute; Pain, Chronic; Cholecystectomy; Ketamine; Dexmedetomidine; Lidocaine; Central Nervous System Depressants; Analgesia; Analgesics; Analgesic Non-narcotic Interventions: Drug: ketamine-lidocaine-dexmedetomidine; Drug: fentanyl Sponsor: Aretaieion University Hospital Not yet recruiting
Condition: Pain Interventions: Drug: Placebo; Drug: Paracetamol Sponsors: University Hospital Inselspital, Berne; Swiss National Science Foundation Not yet recruiting
Burning mouth syndrome (BMS) is a chronic intraoral pain defined by the International Headache Society (IHS) as "an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours/day over more than three months, without clinically evident causative lesions" 1. Symptoms are usually located on the tongue, lips and hard palate 2,3, and are often accompanied by dysgeusia and xerostomia 3,4.
Total pancreatectomy with islet autotransplantation (TPIAT) is a definitive treatment option in appropriately selected patients with debilitating acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) by providing pain relief and an improved quality of life.[1 –6] The secondary goal of TPIAT is to mitigate the challenges of post-pancreatectomy diabetes by autotransplanting the isolated islets into the portal system. While inherent patient and disease characteristics determine who may achieve postoperative insulin independence, with the most consistent p redictor being transplanted islet mass, the physiologic...
An amendment to this paper has been published and can be accessed via the original article.
In this report we review current evidence for selective progesterone receptor modulators and selective androgen receptor modulators as treatment options for benign gynecologic conditions.
Testing for celiac disease is an appropriate diagnostic step in patients presenting with chronic diarrhea and or abdominal pain.1 Patients with irritable bowel syndrome (IBS) and negative celiac tests frequently will attempt a gluten free diet (GFD) nonetheless with varying success. In this issue of Clinical Gastroenterology&Hepatology, Pinto-Sanchez and colleagues provide data to guide recommendations regarding a GFD in patients with IBS.2 They tested for anti-gliadin antibodies in 50 patients with IBS diagnosed base on ROME III criteria.
In the wake of multiple legal challenges, the Biden Administration late last month aimed to fortify the Deferred Action for Childhood Arrivals (DACA) program with a new rule that would shield more than 600,000 undocumented people brought to the U.S. by their parents. While proponents of the program welcomed the move and heralded it an “effort to bulletproof the DACA program,” our response in this moment overlooks a fundamental problem: each challenge on immigration—whether the Muslim Ban, family separation, or challenging DACA—takes a toll on refugee and migrants through vicarious trauma and weather...
A neurologist has pleaded not guilty to federal charges alleging he was a serial sexual abuser of women who had gone to him for help with debilitating, chronic pain