Cancers, Vol. 13, Pages 4939: Use of FOLFIRINOX or Nab-Paclitaxel Plus Gemcitabine for the Treatment of Locally Advanced Pancreatic Adenocarcinoma: A Single Institution Observational Study
Cancers, Vol. 13, Pages 4939: Use of FOLFIRINOX or Nab-Paclitaxel Plus Gemcitabine for the Treatment of Locally Advanced Pancreatic Adenocarcinoma: A Single Institution Observational Study
Cancers doi: 10.3390/cancers13194939
Authors:
Alberto Servetto
Antonio Santaniello
Fabiana Napolitano
Francesca Foschini
Roberta Marciano
Eleonora Mozzillo
Priscilla Cascetta
Anna Rita Amato
Maria Rosaria Augurio
Lucia Maresca
Pietro De De Placido
Sabino De De Placido
Luigi Formisano
Roberto Bianco
Patients with locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC) do not present distant metastases but are not eligible for surgery upfront. Chemotherapy regimens, such as FOLFIRINOX (FFN) or nab-paclitaxel plus gemcitabine (GemNab) in combination with loco-regional treatments are generally used in this setting. However, the best treatment choice is unknown. We retrospectively analyzed the information of 225 patients with stage II–III PDAC treated at our institution between October 2011 and December 2020. A total of 94 patients with LA PDAC who are non-eligible for surgery upfront received neoadjuvant FFN or GemNab. Of the 67 patients receiving FFN, 28 (41.8%) underwent surgery after neoadjuvant therapy. Of the 27 patients treated with GemNab, 6 (22.2%) became eligible for resection. The median overall survival (OS) was 85.1 weeks and 54.3 weeks in the FFN and GemNab groups, respectively (HR = 0.54, p = 0.0109). The median OS was 189.7 weeks and 76.4...
Source: Cancers - Category: Cancer & Oncology Authors: Alberto Servetto Antonio Santaniello Fabiana Napolitano Francesca Foschini Roberta Marciano Eleonora Mozzillo Priscilla Cascetta Anna Rita Amato Maria Rosaria Augurio Lucia Maresca Pietro De De Placido Sabino De De Placido Luigi Formisano Roberto Bianco Tags: Article Source Type: research
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