Genes, Vol. 12, Pages 1537: Influence of Renal Impairment and Genetic Subtypes on Warfarin Control in Japanese Patients

Genes, Vol. 12, Pages 1537: Influence of Renal Impairment and Genetic Subtypes on Warfarin Control in Japanese Patients Genes doi: 10.3390/genes12101537 Authors: Tomotaka Tanaka Masafumi Ihara Kazuki Fukuma Haruko Yamamoto Kazuo Washida Shunsuke Kimura Akiko Kada Shigeki Miyata Toshiyuki Miyata Kazuyuki Nagatsuka The genotypes of vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) can influence therapeutic warfarin doses. Conversely, nongenetic factors, especially renal function, are associated with warfarin maintenance doses; however, the optimal algorithm for considering genes and renal dysfunction has not been established. This single-center prospective cohort study aimed to evaluate the factors affecting warfarin maintenance doses and develop pharmacogenetics-guided algorithms, including the factors of renal impairment and others. To commence, 176 outpatients who were prescribed warfarin for thromboembolic stroke prophylaxis in the stroke center, were enrolled. Patient characteristics, blood test results, dietary vitamin K intake, and CYP2C9 and VKORC1 (−1639G > A) genotypes were recorded. CYP2C9 and VKORC1 (−1639G>A) genotyping revealed that 80% of the patients had CYP2C9*1/*1 and VKORC1 mutant AA genotypes. Multiple linear regression analysis demonstrated that the optimal pharmacogenetics-based model comprised age, body surface area, estimated glomerular filtration rate (eGFR), genotypes, vi...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research