Late Hepatic Toxicity Surveillance for Survivors of Childhood, Adolescent and Young Adult Cancer: Recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Advances in the treatment of childhood, adolescent and young adult (CAYA) cancer have greatly improved 5-year survival, which now exceeds 80% [1 –3]. Unfortunately, many survivors experience long-term morbidity and early mortality resulting from their cancer and/or its treatment [4–6]. Although uncommon, hepatic late complications can lead to substantial morbidity, quality of life impairment and even early mortality. In the Childhood Can cer Survivor Study cohort, the rate of self-reported liver cirrhosis in North American adult survivors of CAYA cancer was 0.2 per 1000 person-years, which was 9 times higher than in sibling controls [7].

Source: Cancer Treatment Reviews - September 18, 2021 Category: Cancer & Oncology Authors: Edit Bardi, Ren ée L Mulder, Elvira C van Dalen, Neel S Bhatt, Kathy A Ruble, Jennifer Burgis, Sharon M Castellino, Louis S Constine, Caroline M den Hoed, Daniel M Green, Bart GP Koot, Gill Levitt, László Szonyi, W Hamish Wallace, Roderick Skinner, Mel Source Type: research