Nutritional ketosis is well-tolerated, even in type 1 diabetes: the ZeroFive100 Project; a proof-of-concept study

The objective of this study was to test the feasibility of exercising over a 5-day period while fasting, in those with and without type 1 diabetes mellitus (T1DM). Eight individuals, ages 29--62 years, two with T1DM, walked/ran around 20 miles per day for five consecutive days while only consuming water. All eight individuals completed the project with no physical injuries or problems with diabetes control. The blood glucose levels ranged from less than 3 mmol/l to 7 mmol/l in those without T1D, and less than 3 mmol/l to 9 mmol/l in those with T1D. The continuous glucose traces in those with T1D showed little variability in glucose levels. The participants without T1D had no symptoms from blood glucose under 3 mmol/l. Ketone levels ranged from 0.3 to 7.5 and the ketones for those with T1D were no different to ketones in those without T1D. The respiratory quotient was overwhelmingly in the fat-burning range. There was very little subjective hunger, nor did it negatively affect mood. In keto-adapted individuals, with or without T1DM, prolonged exercise for 5 days while in nutritional ketosis was feasible, and well tolerated. Recent findings Eight adults, ages 28–62 years, trained for and completed a 5-day zero calorie fast covering 100 miles over 5 days. Training involved each individual preparing for the event according to their own programme. Typically, it involved both cardiovascular and strength training with the addition of practice water only fas...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: OBESITY AND NUTRITION: Edited by Eric C. Westman Source Type: research