Proposing a molecular classification associated with hypercoagulation in ovarian clear cell carcinoma

CONCLUSIONS: CCC represents hypercoagulable disease and elevate D-dimer is a prognostic factor for decreased survival in CCC. D-dimer high CCC has distinct molecular characteristics into the inflammatory-driven pathway (hot tumor) and the immune-suppressive pathway (cold tumor). Treatment implication of our proposed molecular classification merits further investigation.PMID:34452748 | DOI:10.1016/j.ygyno.2021.08.009

Source: Gynecologic Oncology - August 28, 2021 Category: Cancer & Oncology Authors: Ryo Tamura Kosuke Yoshihara Koji Matsuo Nozomi Yachida Ai Miyoshi Kotaro Takahashi Kentaro Sugino Manako Yamaguchi Yutaro Mori Kazuaki Suda Tatsuya Ishiguro Shujiro Okuda Teiichi Motoyama Hirofumi Nakaoka Akira Kikuchi Yutaka Ueda Ituro Inoue Takayuki Eno Source Type: research