P –053 Concentration of bisphenol S in human seminal plasma negatively correlates with decreasing sperm concentration in ejaculate

AbstractStudy questionIs there a relationship between concentration of bisphenol S in seminal fluid and spermiogram parameters?Summary answerBisphenol S was detected in 81% of seminal plasma samples. Negative correlation was found between BPS concentration and total sperm count in normozoospermic men.What is known alreadyHuman spermatogenesis can be influenced by a range of chemicals present in our environment. Bisphenol S (BPS) is a very frequent compound commonly used as a softener in production of plastics, where it has replaced bisphenol A. It is an endocrine disruptor frequently associated with negative effects on reproduction. It has been observed that BPS can affect testicular development in rodent males. In addition, it has cytotoxic, reprotoxic and neurotoxic effects and induces the oxidative stress bringing negative effects on spermatogenesis. BPS has been detected in food, drinks or cosmetics. Its direct effect on spermatozoa or spermatogenesis is still unclear.Study design, size, durationA total of 38 patients (25 normozoospermic) aged 24 to 42 years, non-smokers, with BMI between 19,9 –32,9 were included in this prospective study from 2018 to 2020. None of them had varicocele, urogenital infections or other urological problems. Their seminal plasma was separated by centrifugation. BPS was extracted using solvent extraction followed by preconcentration step. The samples were ana lysed on Agilent 6495 Triple Quadrupole. Two MS/MS transitions were used for quantit...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research