P –300 Metformin: new therapeutic approach for endometriosis-associated infertility

AbstractStudy questionCould endometriosis-associated infertility be mitigated by metformin?Summary answerMetformin treatment restored fertility to control rates in endometriosis-induced mice that present lower fertility. No effect was observed on sham-operated mice.What is known alreadyEndometriosis is a gynaecological disorder characterized by ectopic vascularized endometrial tissue growth, mainly in pelvic cavity, which provokes pain and infertility. Corroborating observations in women, endometriosis decreases oocyte quality and pregnancy success in rodents, without affecting the number of ovulations, resorption rate and fetal weight. Thus, animal models of endometriosis constitute a valuable tool to elucidate the pathophysiology of the disease and putative pharmacological therapies. Metformin is widely used for diabetes type –2 treatment, reducing glucose, oxidative stress and inflammation. Due to its antioxidant properties, metformin has shown to induce regression of endometrial implants in a rat model of endometriosis.Study design, size, durationB6CBA/F1 female mice were randomly divided in groups and subjected to treatment: 1-Endometriosis (n  = 20); 2-Sham-operated (n = 12); 3-Endometriosis with metformin (n = 20); 4-Sham-operated with metformin (n = 20). Endometriosis was surgically induced by heterologous transplantation of endometrium from one donor in receptors from the same strain mice. Implants were confirmed and m onitored by ultrasound. 50mg/k...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research