Autoimmune Encephalitis Resembling Dementia Syndromes

Conclusions Red flags for AIE in patients with suspected dementia are: (1) rapidly progressive cognitive decline, (2) subtle seizures, and (3) abnormalities in ancillary testing atypical for neurodegeneration. Physicians should be aware that inflammatory changes are not always present in AIE, and that biomarkers often requested when dementia was suspected (including 14-3-3) can show abnormal results. Diagnosis is essential as most patients profit from immunotherapy.

http://nn.neurology.org/cgi/content/short/8/5/e1039?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - August 2, 2021 Category: Neurology Authors: Bastiaansen, A. E. M., van Steenhoven, R. W., de Bruijn, M. A. A. M., Crijnen, Y. S., van Sonderen, A., van Coevorden-Hameete, M. H., Nühn, M. M., Verbeek, M. M., Schreurs, M. W. J., Sillevis Smitt, P. A. E., de Vries, J. M., Jan de Jong, F., Titu Tags: Autoimmune diseases, Encephalitis, All Cognitive Disorders/Dementia Article Source Type: research