Pathophysiology of Advanced Heart Failure

This article discusses the most important clinical aspects of advanced HF pathophysiology. It presents the concept of neurohormonal activation and its deleterious effect on cardiovascular system and reflex control. The current theories regarding the role of inflammation, cytokine activation, and myocardial remodeling in HF progression are presented. Advanced HF is a multiorgan syndrome with interplay between cardiovascular system and other organs. The role of iron deficiency is also discussed.

Source: Heart Failure Clinics - July 22, 2021 Category: Cardiology Authors: Jan Biegus, Piotr Niewinski, Krystian Josiak, Katarzyna Kulej, Barbara Ponikowska, Krzysztof Nowak, Robert Zymlinski, Piotr Ponikowski Source Type: research