Death disruptor: how an Australian funnel-web spider may help human hearts

University of Queensland researchers are investigating if protein in venom of Fraser Island spider can stop cardiac cells dyingA protein in the venom of adeadly Australian funnel-web spider may be able to reduce cardiac damage from heart attacks and extend the life of donor hearts used in transplants, according to new research.Venom from the Fraser Island funnel-web, named for the south-east Queensland island where it is found, contains aprotein known as Hi1a.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Heart disease Science Medical research Australia news Queensland Source Type: news

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CONCLUSIONS: TIPE2-hAD-MSCs induce immune tolerance and improve the survival rates of allogeneic heart transplantation in mice. This study is expected to offer an ideal source and target of cells for organ transplantation.PMID:34527344 | PMC:PMC8411184 | DOI:10.21037/jtd-21-1034
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Authors: Source Type: research
Neth Heart J. 2021 Sep 15. doi: 10.1007/s12471-021-01627-x. Online ahead of print.ABSTRACTThe updated listing criteria for heart transplantation are presented on behalf of the three heart transplant centres in the Netherlands. Given the shortage of donor hearts, selection of those patients who may expect to have the greatest benefit from a scarce societal resource in terms of life expectancy and quality of life is inevitable. The indication for heart transplantation includes end-stage heart disease not remediable by more conservative measures, accompanied by severe physical limitation while on optimal medical therapy, incl...
Source: Netherlands Heart Journal - Category: Cardiology Authors: Source Type: research
Expert Rev Cardiovasc Ther. 2021 Sep 13. doi: 10.1080/14779072.2021.1977124. Online ahead of print.ABSTRACTINTRODUCTION: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a progressive, life-limiting disease.AREAS COVERED: In this paper, we review the classification and pathophysiology of PAH-CHD, including the mechanisms of disease progression and multisystem effects of disease. We evaluate current strategies of risk stratification and the use of biological markers of disease severity, and review principles of management of PAH-CHD. The indications, timing and the content of advanced he...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Authors: Source Type: research
AbstractIn this review we provide a brief description of recently published articles addressing topics relevant to pediatric cardiologists. Our hope is to provide a summary of the latest articles published recently in other journals in our field. The articles address (1) a summary of a scientific statement of the American Heart Association for diagnosis and treatment of myocarditis, (2) development of a perioperative risk score for in-hospital mortality after cardiac surgery in adults with congenital heart disease, (3) using a machine learning algorithm to predict cardiopulmonary deterioration in patients in the interstage...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
ConclusionThe ARTORIA-R will provide robust information on current management and outcomes of adults with congenital heart disease suffering from advanced heart failure.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Study Design Source Type: research
AbstractMesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplan...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
On Sept. 7, the country’s leading COVID-19 doctor issued a dire warning about the growing number of pandemic cases in the country, and the shrinking number of ICU beds available to care for the sickest people. Speaking on CNN, Dr. Anthony Fauci, the chief White House medical advisor, said we are “perilously close in certain areas of the country of getting so close to having full occupancy that you’re going to be in a situation where you’re going to have to make some tough choices.” Those tough choices, he admitted, include discussions about whether scarce resources should go to people who have...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
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