Safety and Tolerability of SARS-CoV-2 Emergency-Use Authorized Vaccines Allogeneic Hematopoietic Stem Cell Transplant Recipients.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) is a novel coronavirus emerging from Wuhan, China that can cause severe respiratory illness and a myriad of other complications that is now known as COVID-19. This disease was declared a pandemic by World Health Organization in March 2020 and has affected hundreds of millions of people worldwide1. COVID-19  clinical presentations can vary greatly between patients and those who are at highest risk for severe illness leading to hospitalization and/or death include older age, obesity, diabetes, and immunocompromised state, amongst other conditions2.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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ConclusionsThe changes in the spike protein of emerging variants, immunomodulation by viral proteins, and altered expression of host viral entry receptor in pre-existing diseases are the key determinants of host response to SARS-CoV2 and its disease outcome.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
World J Hepatol. 2021 Sep 27;13(9):969-978. doi: 10.4254/wjh.v13.i9.969.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic may present with a broad range of clinical manifestations, from no or mild symptoms to severe disease. Patients with specific pre-existing comorbidities, such as obesity and type 2 diabetes, are at high risk of coming out with a critical form of COVID-19. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and, because of its frequent association with metabolic alterations including obesity and type 2 diabetes, it has recently been re-named as metabolic-associated ...
Source: World Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: Optimum diabetes control and adherence to good self-care practices is the need of hour, and contingency plans for medicines and diabetes care supplies are of utmost importance in these testing times.PMID:34568131 | PMC:PMC8415684 | DOI:10.4103/jfmpc.jfmpc_1896_20
Source: Primary Care - Category: Primary Care Authors: Source Type: research
Background: The global pandemic Coronavirus Disease 2019 (COVID-19) due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is reported to be potentially severe in patients with morbid conditions. One common reported comorbidities is diabetes. We aimed in this study to precise the clinical characteristics and outcomes in a series of congolese diabetic patients affected by COVID-19 infection.Patients and methods: We retrospectely studied from 256 COVID-19 patients, a cohort of 30 persons with previously known diabetes. The glycaemia controls have been obtained by plasma glucose assay. All patients have been ...
Source: African Health Sciences - Category: African Health Authors: Source Type: research
CONCLUSION: A combination of underlying chronic conditions such as hypertension, obesity, and cardiovascular diseases together with altered ACE receptor expression, immune dysregulation via cytokine storm, alveolar and endothelial dysfunction, increased systemic coagulation may put individuals with diabetes at risk for COVID-19 severity. More studies are needed to elucidate how glucose-lowering drugs may modulate the host immune response in diabetic individuals, especially following the administration of potential COVID-19 vaccines.PMID:34365925 | DOI:10.2174/1573399817666210806104349
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Source Type: research
Nutr Hosp. 2021 Jun 28. doi: 10.20960/nh.03469. Online ahead of print.ABSTRACTINTRODUCTION: coronavirus disease 2019 (COVID-19) encompasses a wide spectrum of symptoms, including respiratory, gastrointestinal, hematological, and dermatological manifestations. The virus interaction with cells located in the respiratory tract causes the release of inflammatory mediators, whose involvement could be exacerbated by co-existing obesity, diabetes, and cardiovascular events.OBJECTIVES: the objective of this research was to analyze the clinically metabolic status in patients who have suffered COVID-19 disease in order to predict th...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Source Type: research
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-li...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study is par for the course, looking at Japanese Olympic participants. Interestingly, it hints at the upper end of the dose-response curve for physical activity, in that a longer career as a professional athlete may be detrimental in comparison to lesser degrees of exercise and training. From this large, retrospective cohort study targeting 3546 Japanese Olympic athletes, we observed significant lower mortality among Olympians compared with the Japanese general population. The overall standardised mortality ratio (SMR) was 0.29. The results were consistent with previous studies conducted in other non-Asian co...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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