Molecules, Vol. 26, Pages 3389: Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders

Molecules, Vol. 26, Pages 3389: Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders Molecules doi: 10.3390/molecules26113389 Authors: Ishtiaq Ahmed Saif Ur Rehman Shiva Shahmohamadnejad Muhammad Anjum Zia Muhammad Ahmad Muhammad Muzammal Saeed Zain Akram Hafiz M. N. Iqbal Qingyou Liu In humans, various sites like cannabinoid receptors (CBR) having a binding affinity with cannabinoids are distributed on the surface of different cell types, where endocannabinoids (ECs) and derivatives of fatty acid can bind. The binding of these substance(s) triggers the activation of specific receptors required for various physiological functions, including pain sensation, memory, and appetite. The ECs and CBR perform multiple functions via the cannabinoid receptor 1 (CB1); cannabinoid receptor 2 (CB2), having a key effect in restraining neurotransmitters and the arrangement of cytokines. The role of cannabinoids in the immune system is illustrated because of their immunosuppressive characteristics. These characteristics include inhibition of leucocyte proliferation, T cells apoptosis, and induction of macrophages along with reduced pro-inflammatory cytokines secretion. The review seeks to discuss the functional relationship between the endocannabinoid system (ECS) and anti-tumor characteristics of cannabinoids in various cancers. The therapeutic potential of cannabinoids for cancer—both in vivo and in vitro clinical trials...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research