Regulation of hepatic fibrosis by Carcinoembryonic Antigen-related Cell Adhesion Molecule 1

NAFLD is a complex disease marked by cellular abnormalities leading to NASH. NAFLD patients manifest low hepatic levels of CEACAM1, a promoter of insulin clearance. Consistently, Cc1 –/– null mice displayed spontaneous hyperinsulinemia/insulin resistance and steatohepatitis. Liver-specific reconstitution of Ceacam1 reversed these metabolic anomalies in 8-month-old Cc1–/–xliver+ mice fed a regular chow diet. The current study examined whether it would also reverse progres sive hepatic fibrosis in mice fed a high-fat (HF) diet.

Source: Metabolism - Clinical and Experimental - May 27, 2021 Category: Biomedical Science Authors: Raghd Abu Helal, Lucia Russo, Hilda E. Ghadieh, Harrison T. Muturi, Suman Asalla, Abraham D. Lee, Cara Gatto-Weis, Sonia M. Najjar Source Type: research