Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons

In conclusion, iPSC-DSN are a promising platform to study the pathogenesis of CIPN and to evaluate neuroprotective treatment strategies. In the future, the application of patient-specific iPSC-DSN could open new avenues for personalized medicine with individual risk prediction, choice of chemotherapeutic compounds and preventive treatments.PMID:33984509 | DOI:10.1016/j.nbd.2021.105391

Source: Neurobiology of Disease - May 13, 2021 Category: Neurology Authors: Christian Schinke Valeria Fernandez Vallone Andranik Ivanov Yangfan Peng P éter Körtvelyessy Luca Nolte Petra Huehnchen Dieter Beule Harald Stachelscheid Wolfgang Boehmerle Matthias Endres Source Type: research