Chronic administration of pharmacological doses of angiotensin 1 ‐7 and iodoangiotensin 1‐7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats

This study evaluated chronic high ‐dose iodotyr(4)angiotensin 1‐7 and angiotensin 1‐7 administration on blood pressure, heart rate and cognitive function in SHR. Iodotyr(4)angiotensin 1‐7 and angiotensin 1‐7 prevented the increase in heart rate over a 27 day period but did not alter blood pressure or performance in a long ‐term recognition test or a short‐term spatial memory task. AbstractCardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1 –7 (Ang 1‐7), a product of the renin‐angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. Recent data from our lab reveals that the addition of a non‐radioactive iodine molecule to the tyrosine in position 4 of Ang 1‐7 (iodoAng 1‐7) makes it ~1000‐fold more p otent than Ang 1‐7 in competing for the125I ‐Ang 1‐7 binding site (Stoyell‐Conti et al., 2020). Moreover, the addition of the non‐radioactive iodine molecule increases (~4‐fold) iodoAng 1‐7’s ability to bind to the AT1 receptor (AT1R), the primary receptor for Ang II. Preliminary data indicates that iodoAng 1‐7 can also compet e for the125I ‐Ang IV binding site with a low micromolar IC50. Thus, our aims were to compare the effects of chronic treatment of the Spontaneou...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL ARTICLE Source Type: research