HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoter

Conclusions: HDAC1/2 contributes to VCAM-1 expression and atherosclerosis by suppressing STAT3 acetylation-dependent GATA6 promoter methylation. These findings may provide a rationale for HDAC1/2-targeting therapy in atherosclerotic heart disease.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chengxiu Hu, Kai Peng, Qianqian Wu, Yiying Wang, Xing Fan, Dai-Min Zhang, Anthony G. Passerini, ChongXiu Sun Tags: Research Paper Source Type: research