Cancers, Vol. 13, Pages 1732: Substance P Antagonism Prevents Chemotherapy-Induced Cardiotoxicity

Conclusions: Our studies indicate that the SP/NK1-R system is a key mediator that induces, DOX-induced, cardiac dysfunction, cardiac apoptosis, cardiac oxidative stress and cardiomyocyte hypertrophy. These studies implicate that NK-1R antagonists may serve as a novel therapeutic tool for prevention of chemotherapy induced cardiotoxicity in cancer.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research