Ursodeoxycholic acid and liver disease associated with cystic fibrosis: A multicenter cohort study
Liver disease is a common complication in cystic fibrosis (CF) that occurs mainly during the first and second decade of life with a prevalence of about 30% at 12 years of age [1 –3]. In the advanced stage, it is associated with pulmonary function decline, deterioration of nutritional status and increased risk of death [4]. Longitudinal studies found that 20-30% of CF subjects will develop focal biliary cirrhosis and 5-10% multilobular cirrhosis [2], which is often complic ated by portal hypertension (PH).
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Carla Colombo, Gianfranco Alicandro, Mark Oliver, Peter J Lewindon, Grant A Ramm, Chee Y. Ooi, Federico Alghisi, Nataliya Kashirskaya, Elena Kondratyeva, Fabiola Corti, Rita Padoan, Irina Asherova, Helen Evans, Isabelle de Monestrol, Birgitta Strandvik, A Tags: Original Article Source Type: research
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