Endothelin B receptors impair baroreflex function and increase blood pressure variability during high salt diet

Baroreflex function is an integral component maintaining consistent blood pressure. Hypertension is often associated with baroreflex dysfunction, and environmental risk factors such as high salt diet exacerbate hypertension in subjects with baroreflex dysfunction. However, the interactions between high salt diet, baroreflex dysfunction, and hypertension are incompletely understood. The endothelin system is another potent mediator of blood pressure control especially in response to a high salt diet.

Source: Autonomic Neuroscience: Basic and Clinical - March 10, 2021 Category: Neuroscience Authors: Bryan K. Becker, Jermaine G. Johnston, Carolyn Young, Alfredo A. Torres Rodriguez, Chunhua Jin, David M. Pollock Source Type: research