Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes: Meta-Analyses and Mendelian Randomization Analyses

CONCLUSIONS: The present meta-analysis discovered several proteins related to carotid atherosclerosis that partly differed in their association with IMT-CCA, plaque, and incident atherosclerotic disease. Mendelian randomization analysis for the top finding, MMP-12, suggests that the increased levels of MMP-12 could be a consequence of atherosclerotic burden rather than the opposite chain of events.PMID:33657885 | DOI:10.1161/ATVBAHA.120.315597

Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 4, 2021 Category: Cardiology Authors: Lars Lind Bruna Gigante Yan Born é Tobias Feldreich Jerzy Leppert P är Hedberg Carl Johan Östgren Fredrik H Nystr öm Johan Sundstr öm Johan Ärnlöv Damiano Baldassarre Elena Tremoli Fabrizio Veglia Anders Hamsten Christopher J O'Donnell Nora Frances Source Type: research