Abstract A07: Novel effectors of K-Ras-mediated and KSR1 dependent colon tumorigenesis

Conclusion: These results demonstrate the importance of AMPK and its downstream signaling effectors PGC1β and ERRα in maintaining colon tumor cell survival driven by oncogenic Ras and demonstrate the value of using KSR1 as a reference standard to detect genes essential to colon tumor survival.Citation Format: Binita Das, Kurt Fisher, Hyunseok Kim, Deanna J. Volle, Deandra R. Smith, Robert S. Livergood, John MacMillan, Michael White, Robert Lewis. Novel effectors of K-Ras-mediated and KSR1 dependent colon tumorigenesis. [abstract]. In: Proceedings of the AACR Special Conference on RAS Oncogenes: From Biology to Therapy; Feb 24-27, 2014; Lake Buena Vista, FL. Philadelphia (PA): AACR; Mol Cancer Res 2014;12(12 Suppl):Abstract nr A07. doi: 10.1158/1557-3125.RASONC14-A07

Source: Molecular Cancer Research - February 5, 2015 Category: Cancer & Oncology Authors: Das, B., Fisher, K., Kim, H., Volle, D. J., Smith, D. R., Livergood, R. S., MacMillan, J., White, M., Lewis, R. Tags: RAS Effectors - Basic Biology: Poster Presentations - Proffered Abstracts Source Type: research